DHA Supplementation Attenuates MI-Induced LV Matrix Remodeling and Dysfunction in Mice.
I HabichtG MohsenL EichhornS FredeC WeisheitTobias HilbertH TreedeE GüresirO DewaldGeorg Daniel DuerrMarkus VeltenPublished in: Oxidative medicine and cellular longevity (2020)
Our data indicate that DHA supplementation mediates cardioprotection from MI via modulation of the inflammatory response with timely and attenuated remodeling. DHA seems to attenuate MI-induced cardiomyocyte injury partly by transient PPAR-α downregulation, diminishing the need for antioxidant mechanisms including mitochondrial function, or α- to β-MHC isoform switch.
Keyphrases
- high glucose
- inflammatory response
- fatty acid
- diabetic rats
- oxidative stress
- endothelial cells
- drug induced
- type diabetes
- signaling pathway
- cell proliferation
- insulin resistance
- electronic health record
- machine learning
- adipose tissue
- immune response
- big data
- angiotensin ii
- toll like receptor
- deep learning
- skeletal muscle
- blood brain barrier
- stress induced
- artificial intelligence