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FABP4 blocker attenuates colonic hypomotility and modulates white adipose tissue-derived hormone levels in mouse models mimicking constipation-predominant IBS.

P MosińskaD JacenikM SałagaA WasilewskiA CygankiewiczA SibaevA MokrowieckaE Małecka-PanasI PintelonM StorrJ P TimmermansW M KrajewskaJakub Fichna
Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2017)
Fatty acid binding protein 4 may be involved in IBS pathogenesis and become a novel target in the treatment of constipation-related diseases.
Keyphrases
  • irritable bowel syndrome
  • binding protein
  • adipose tissue
  • fatty acid
  • mouse model
  • insulin resistance
  • high fat diet
  • type diabetes
  • ulcerative colitis
  • skeletal muscle
  • angiotensin ii
  • drug induced
  • smoking cessation