Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma.

Charles MarusakVijay S Thakur Yuan Li Juliano T FreitasPatrick M ZminaMayland ChangMing GaoJiufeng TanMin XiaoYiling LuGordon B MillsKeith FlahertyDennie T FrederickBenchun MiaoRyan J SullivanTabea O C Moll Genevieve Marie BolandMeenhard HerlynGao Zhang Barbara Bedogni

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

BRAF inhibition results in a selective pressure toward higher expression of MT1-MMP. MT1-MMP is pivotal to an ECM-based signaling pathway that confers resistance to BRAFi therapy.

Keyphrases

extracellular matrix
signaling pathway
metastatic colorectal cancer
poor prognosis
cell migration
wild type
pi k akt
epithelial mesenchymal transition
cancer therapy
binding protein
induced apoptosis
stem cells
skin cancer
drug delivery