Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites.
Ariane ZamarioliZachery R CampbellKevin A MaupinPaul J ChildressJoao P B XimenezGremah AdamNabarun ChakrabortyAarti GautamRasha HammamiehIzath Nizeet AguilarPublished in: NPJ microgravity (2021)
With increased human presence in space, bone loss and fractures will occur. Thrombopoietin (TPO) is a recently patented bone healing agent. Here, we investigated the systemic effects of TPO on mice subjected to spaceflight and sustaining a bone fracture. Forty, 9-week-old, male, C57BL/6 J were divided into 4 groups: (1) Saline+Earth; (2) TPO + Earth; (3) Saline+Flight; and (4) TPO + Flight (n = 10/group). Saline- and TPO-treated mice underwent a femoral defect surgery, and 20 mice were housed in space ("Flight") and 20 mice on Earth for approximately 4 weeks. With the exception of the calvarium and incisor, positive changes were observed in TPO-treated, spaceflight bones, suggesting TPO may improve osteogenesis in the absence of mechanical loading. Thus, TPO, may serve as a new bone healing agent, and may also improve some skeletal properties of astronauts, which might be extrapolated for patients on Earth with restraint mobilization and/or are incapable of bearing weight on their bones.
Keyphrases
- bone loss
- high fat diet induced
- bone mineral density
- newly diagnosed
- soft tissue
- bone regeneration
- clinical trial
- randomized controlled trial
- physical activity
- mass spectrometry
- metabolic syndrome
- weight loss
- prognostic factors
- skeletal muscle
- recombinant human
- atrial fibrillation
- single molecule
- induced pluripotent stem cells
- atomic force microscopy