Dppa3 in pluripotency maintenance of ES cells and early embryogenesis.
Shuang ZhaoJia XuSiying LiuKaige CuiZongjin LiNa LiuPublished in: Journal of cellular biochemistry (2018)
Embryonic development is precisely regulated by a network of signal pathways and specific genes. Dppa3 (also known as Pgc7 or Stella) plays an important role in early embryonic development during the cleavage stage as a maternal effect gene. Dppa3 expresses in many species, and its homologous gene in human and rat genomes is located at the same chromosomal regions and have the same exon-intron structure. However, unlike mouse embryonic stem (ES) cells, in which the Dppa3 promoter maintains hypomethylation that allows a high transcription level, the DPPA3 promoter region in human ES cells is methylated, much like that of mouse epiblast stem cell. Dppa3 is essential for early embryogenesis and pluripotency maintenance; however, the precise mechanism and downstream passage remains unknown. In this review, we will summarize some important functions of Dppa3 in early embryogenesis and pluripotency maintenance of mouse ES cells.
Keyphrases
- induced apoptosis
- cell cycle arrest
- stem cells
- dna methylation
- genome wide identification
- transcription factor
- genome wide
- oxidative stress
- endoplasmic reticulum stress
- copy number
- body mass index
- dna damage
- cell proliferation
- embryonic stem cells
- dna binding
- induced pluripotent stem cells
- pluripotent stem cells
- birth weight
- gestational age
- pregnancy outcomes