Login / Signup

Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression.

Ross J DarlingSujata SenapatiJohn ChristiansenLuman LiuAmanda E Ramer-TaitBalaji NarasimhanMichael J Wannemuehler
Published in: International journal of nanomedicine (2020)
Together, these results suggest that the use of a polyanhydride-based nanovaccine can be an effective approach to inducing antigen-specific CD8+ T cell memory by providing antigen delivery and DC activation while avoiding overt inflammatory responses typically associated with traditional adjuvants.
Keyphrases
  • dendritic cells
  • working memory
  • regulatory t cells
  • poor prognosis
  • oxidative stress
  • immune response