The Effects of Acute and Chronic Alcohol Administration and Withdrawal on Bone Microstructure, Mechanical Strength, and Remodeling Protein Expression and Their Relation to an Antioxidant and FGF23 In Vivo.
Syed Alhafiz Syed HashimIsa Naina MohamedNorazlina MohamedPublished in: Biomedicines (2024)
Alcohol's detrimental effects on bone health are well established, yet some literature suggests moderate consumption may offer benefits. With alcohol use on the rise, we investigate the impact of acute and chronic alcohol administration, along with withdrawal, on male Wistar rat femurs. We observed a transient cortical thickness increase with acute alcohol (AA) compared to chronic exposure (CA) but no significant changes in trabecular parameters or mechanical properties. High osteocalcin and osteopontin expression levels were noted in AA, alongside elevated RANKL expression. Conversely, CA showed low TRAP levels. FGF23 expression significantly increased during alcohol withdrawal (AW), while GPX decreased after chronic exposure but rose during withdrawal. Although mechanical strength changes were insignificant, biochemical shifts suggest alcohol exposure promotes bone resorption, reduces antioxidant protection, and potentially hampers active vitamin D and phosphate reabsorption via FGF23 upregulation.
Keyphrases
- poor prognosis
- liver failure
- alcohol consumption
- drug induced
- bone mineral density
- bone loss
- oxidative stress
- respiratory failure
- healthcare
- public health
- systematic review
- mental health
- bone regeneration
- long non coding rna
- immune response
- aortic dissection
- multiple sclerosis
- anti inflammatory
- intensive care unit
- inflammatory response
- social media
- high intensity
- optical coherence tomography
- climate change
- subarachnoid hemorrhage