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"Kissing" basaloid follicular hamartomas of the eyelid.

Ogechi EzemmaSara D RagiRenata RuizLeslie Robinson-BostomYoash EnzerChristopher DiMarco
Published in: Journal of cutaneous pathology (2022)
Basaloid follicular hamartomas (BFHs) are rare, benign, cutaneous adnexal tumors characterized by branching cords and anastomosing strands of basaloid cells in a loose, fibrous stroma. BFHs exhibit variable clinical presentations although they are commonly observed as skin-colored papules and are diagnosed based on histopathological features. Common systemic diseases associated with BFH include alopecia, myasthenia gravis, and palmoplantar pitting. BFH of the eyelid is extremely rare with only five cases reported in the literature to date. Congenital "kissing" lesions have only previously been reported with nevi. Here, we present a novel case of congenital "kissing" BFH of the right upper and right lower eyelid, and histopathological examination revealed intradermal nodules of basaloid cells forming reticulated strands, pseudohorn cysts, mucinous stroma, and palisading with CD34 and Bcl-2 expression in the stromal fibroblasts and periphery, respectively.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • myasthenia gravis
  • poor prognosis
  • endoplasmic reticulum stress
  • signaling pathway
  • low grade
  • binding protein
  • long non coding rna
  • high grade
  • soft tissue
  • pi k akt