Fate-mapping analysis using Rorb-IRES-Cre reveals apical-to-basal gradient of Rorb expression in mouse cochlea.

Chao LiYunfeng WangGuangqin WangYing LuShunji HeYuwei SunZhiyong Liu

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2019)

We reveal that Rorb expression exhibits an apical-to-basal gradient in cochleae. The cochlear-specific and apical-to-basal-gradient Rorb Cre activity should enable discrimination of gene functions in cochlear vs vestibular regions as well as low-frequency vs high-frequency regions in the cochlea.

Keyphrases

high frequency
poor prognosis
transcranial magnetic stimulation
hearing loss
genome wide
high resolution
binding protein
long non coding rna
single cell
copy number