Comparison of 13 C MRI of hyperpolarized [1-13 C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model.
Maria FalaVencel SomaiAndreas DannhornGregory HammKatherine GibsonDominique-Laurent CouturierRichard HeskethAlan J WrightZoltan TakatsJosephine BunchSimon T BarryRichard J A GoodwinKevin M BrindlePublished in: Magnetic resonance in medicine (2021)
The inhomogeneous distribution of labeled lactate observed in the MRS images was confirmed by MS imaging of the corresponding tumor sections. The images acquired using both techniques show that the rate of 13 C label exchange between the injected pyruvate and endogenous tumor lactate pool is more correlated with the rate of pyruvate delivery to the tumor cells and is less affected by the endogenous lactate concentration.
Keyphrases
- mass spectrometry
- deep learning
- convolutional neural network
- optical coherence tomography
- high resolution
- magnetic resonance imaging
- multiple sclerosis
- liquid chromatography
- diffuse large b cell lymphoma
- contrast enhanced
- high performance liquid chromatography
- pet imaging
- computed tomography
- machine learning
- photodynamic therapy
- diffusion weighted imaging
- positron emission tomography