Kevin M Brindle (Kevin Brindle, K M Brindle)

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 43

Top Topics

Magnetic Resonance

Diffusion Weighted Imaging

Prostate Cancer

Top Venues

NMR in biomedicine

Cancer research

Magnetic resonance in medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Jacob Chen Ming Low, Jianbo Cao, Friederike Hesse, Alan J Wright, Anastasia Tsyben, Islam Alshamleh, Richard Mair, Kevin M Brindle
Deuterium metabolic imaging differentiates glioblastoma metabolic subtypes and detects early response to chemoradiotherapy. Cancer research (2024)
Friederike Hesse, Jacob Low, Jianbo Cao, Flaviu Bulat, Felix Kreis, Alan J Wright, Kevin M Brindle
Deuterium MRI of serine metabolism in mouse models of glioblastoma. Magnetic resonance in medicine 92 (5) (2024)
Friederike Hesse, Jacob Low, Jianbo Cao, Flaviu Bulat, Felix Kreis, Alan J Wright, Kevin M Brindle
Deuterium MRI of serine metabolism in mouse models of glioblastoma. Magnetic resonance in medicine (2024)
Jacob Chen Ming Low, Jianbo Cao, Friederike Hesse, Alan J Wright, Anastasia Tsyben, Islam Alshamleh, Richard Mair, Kevin M Brindle
Deuterium metabolic imaging differentiates glioblastoma metabolic subtypes and detects early response to chemoradiotherapy. Cancer research (2024)
Jacob Chen Ming Low, Jianbo Cao, Friederike Hesse, Alan J Wright, Anastasia Tsyben, Islam Alshamleh, Richard Mair, Kevin M Brindle
Deuterium Metabolic Imaging Differentiates Glioblastoma Metabolic Subtypes and Detects Early Response to Chemoradiotherapy. Cancer research 84 (12) (2024)
Jacob Chen Ming Low, Jianbo Cao, Friederike Hesse, Alan J Wright, Anastasia Tsyben, Islam Alshamleh, Richard Mair, Kevin M Brindle
Deuterium Metabolic Imaging Differentiates Glioblastoma Metabolic Subtypes and Detects Early Response to Chemoradiotherapy. Cancer research 84 (12) (2024)
Jacob Chen Ming Low, Jianbo Cao, Friederike Hesse, Alan J Wright, Anastasia Tsyben, Islam Alshamleh, Richard Mair, Kevin M Brindle
Deuterium Metabolic Imaging Differentiates Glioblastoma Metabolic Subtypes and Detects Early Response to Chemoradiotherapy. Cancer research 84 (12) (2024)
Maria Fala, Susana Ros, Ashley Sawle, Jyotsna U Rao, Anastasia Tsyben, Laura Tronci, Christian Frezza, Richard Mair, Kevin M Brindle
The role of branched-chain aminotransferase 1 in driving glioblastoma cell proliferation and invasion varies with tumor subtype. Neuro-oncology advances 5 (1) (2023)
Flaviu Bulat, Friederike Hesse, Bala Attili, Chandra Solanki, Iosif A Mendichovszky, Franklin Aigbirhio, Finian J Leeper, Kevin M Brindle, André A Neves
Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am. Cancers 15 (5) (2023)
Friederike Hesse, Alan Wright, Flaviu Bulat, Felix Kreis, Kevin M Brindle
Assessment of the sensitivity of 2 H MR spectroscopy measurements of [2,3- 2 H 2 ]fumarate metabolism for detecting tumor cell death. NMR in biomedicine (2023)
Flaviu Bulat, Friederike Hesse, Bala Attili, Chandra Solanki, Iosif A Mendichovszky, Franklin Aigbirhio, Finian J Leeper, Kevin M Brindle, André A Neves
Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am. Cancers 15 (5) (2023)
Friederike Hesse, Alan Wright, Flaviu Bulat, Felix Kreis, Kevin M Brindle
Assessment of the sensitivity of 2 H MR spectroscopy measurements of [2,3- 2 H 2 ]fumarate metabolism for detecting tumor cell death. NMR in biomedicine (2023)
Daniel R Parle, Flaviu Bulat, Shahd Fouad, Heather Zecchini, Kevin M Brindle, André A Neves, Finian J Leeper
Metabolic Glycan Labeling of Cancer Cells Using Variably Acetylated Monosaccharides. Bioconjugate chemistry 33 (8) (2022)
Nikita Sushentsev, Mary A McLean, Anne Y Warren, Arnold J V Benjamin, Cara Brodie, Amy Frary, Andrew B Gill, Julia Jones, Joshua D Kaggie, Benjamin W Lamb, Matthew J Locke, Jodi L Miller, Ian G Mills, Andrew N Priest, Fraser J L Robb, Nimish Shah, Rolf F Schulte, Martin John Graves, Vincent J Gnanapragasam, Kevin M Brindle, Tristan Barrett, Ferdia A Gallagher
Author Correction: Hyperpolarised 13 C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer. Nature communications 13 (1) (2022)
Nikita Sushentsev, Mary A McLean, Anne Y Warren, Arnold J V Benjamin, Cara Brodie, Amy Frary, Andrew B Gill, Julia Jones, Joshua D Kaggie, Benjamin W Lamb, Matthew J Locke, Jodi L Miller, Ian G Mills, Andrew N Priest, Fraser J L Robb, Nimish Shah, Rolf F Schulte, Martin John Graves, Vincent J Gnanapragasam, Kevin M Brindle, Tristan Barrett, Ferdia A Gallagher
Hyperpolarised 13 C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer. Nature communications 13 (1) (2022)
David Crosby, Sangeeta N Bhatia, Kevin M Brindle, Lisa M Coussens, Caroline Dive, Mark Emberton, Sadik C Esener, Rebecca C Fitzgerald, Sanjiv Sam Gambhir, Peter Kuhn, Timothy R Rebbeck, Samantha Kendrick
Early detection of cancer. Science (New York, N.Y.) 375 (6586) (2022)
Friederike Hesse, Alan J Wright, Vencel Somai, Flaviu Bulat, Felix Kreis, Kevin M Brindle
Imaging Glioblastoma Response to Radiotherapy Using 2H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism. Cancer research 82 (19) (2022)
Friederike Hesse, Alan J Wright, Flaviu Bulat, Vencel Somai, Felix Kreis, Kevin M Brindle
Deuterium MRSI of tumor cell death in vivo following oral delivery of 2 H-labeled fumarate. Magnetic resonance in medicine 88 (5) (2022)
Stephan Ursprung, Ramona Woitek, Mary A McLean, Andrew N Priest, Mireia Crispin-Ortuzar, Cara R Brodie, Andrew B Gill, Marcel Gehrung, Lucian Beer, Antony C P Riddick, Johanna Field-Rayner, James T Grist, Surrin Shazam Deen, Frank Riemer, Joshua D Kaggie, Fulvio Zaccagna, Joao A G Duarte, Matthew J Locke, Amy Frary, Tevita F Aho, James N Armitage, Ruth Casey, Iosif A Mendichovszky, Sarah J Welsh, Tristan Barrett, Martin J Graves, Tim Eisen, Thomas J Mitchell, Anne Y Warren, Kevin M Brindle, Evis Sala, Grant D Stewart, Ferdia A Gallagher
Hyperpolarized 13 C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma-A Proof of Principle Study. Cancers 14 (2) (2022)
Fulvio Zaccagna, Mary A McLean, James T Grist, Joshua D Kaggie, Richard Mair, Frank Riemer, Ramona Woitek, Andrew B Gill, Surrin Shazam Deen, Charlie J Daniels, Stephan Ursprung, Rolf F Schulte, Kieren Allinson, Anita Chhabra, Marie-Christine Laurent, Matthew Locke, Amy Frary, Sarah Hilborne, Ilse Patterson, Bruno D Carmo, Rhys Slough, Ian Wilkinson, Bristi Basu, James Wason, Jonathan H Gillard, Tomasz Matys, Colin Watts, Stephen John Price, Thomas Santarius, Martin J Graves, Sarah Jefferies, Kevin M Brindle, Ferdia A Gallagher
Imaging Glioblastoma Metabolism by Using Hyperpolarized [1- 13 C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study. Radiology. Imaging cancer 4 (4) (2022)
Cristina Barca, Christoph M Griessinger, Andreas Faust, Dominic Depke, Markus Essler, Albert D Windhorst, Nick Devoogdt, Kevin M Brindle, Michael Schäfers, Bastian Zinnhardt, Andreas H Jacobs
Expanding Theranostic Radiopharmaceuticals for Tumor Diagnosis and Therapy. Pharmaceuticals (Basel, Switzerland) 15 (1) (2021)
Friederike Hesse, Vencel Somai, Felix Kreis, Flaviu Bulat, Alan J Wright, Kevin M Brindle
Monitoring tumor cell death in murine tumor models using deuterium magnetic resonance spectroscopy and spectroscopic imaging. Proceedings of the National Academy of Sciences of the United States of America 118 (12) (2021)
Jonathan C M Wan, Katrin Heider, Davina Gale, Suzanne Murphy, Eyal Fisher, Florent Mouliere, Andrea Ruiz-Valdepenas, Angela Santonja, James Morris, Dineika Chandrananda, Andrea Marshall, Andrew B Gill, Pui Ying Chan, Emily Barker, Gemma Young, Wendy N Cooper, Irena Hudecova, Francesco Marass, Richard Mair, Kevin M Brindle, Grant D Stewart, Jean E Abraham, Carlos Caldas, Doris M Rassl, Robert C Rintoul, Constantine Alifrangis, Mark Ross Middleton, Ferdia A Gallagher, Christine Parkinson, Amer Durrani, Ultan McDermott, Christopher G Smith, Charles E Massie, Philippa Corrie, Nitzan Rosenfeld
ctDNA monitoring using patient-specific sequencing and integration of variant reads. Science translational medicine 12 (548) (2021)
Florent Mouliere, Christopher G Smith, Katrin Heider, Jing Su, Ymke van der Pol, Mareike Thompson, James Morris, Jonathan C M Wan, Dineika Chandrananda, James Hadfield, Marta Grzelak, Irena Hudecova, Dominique-Laurent Couturier, Wendy N Cooper, Hui Zhao, Davina Gale, Matthew Eldridge, Colin Watts, Kevin M Brindle, Nitzan Rosenfeld, Richard Mair
Fragmentation patterns and personalized sequencing of cell-free DNA in urine and plasma of glioma patients. EMBO molecular medicine 13 (8) (2021)
Maria Fala, Vencel Somai, Andreas Dannhorn, Gregory Hamm, Katherine Gibson, Dominique-Laurent Couturier, Richard Hesketh, Alan J Wright, Zoltan Takats, Josephine Bunch, Simon T Barry, Richard J A Goodwin, Kevin M Brindle
Comparison of 13 C MRI of hyperpolarized [1-13 C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model. Magnetic resonance in medicine 85 (6) (2021)
Ramona Woitek, Mary A McLean, Stephan Ursprung, Oscar M Rueda, Raquel Manzano Garcia, Matthew J Locke, Lucian Beer, Gabrielle Baxter, Leonardo Rundo, Elena Provenzano, Joshua Kaggie, Andrew Patterson, Amy Frary, Johanna Field-Rayner, Vasiliki Papalouka, Justine Kane, Arnold J V Benjamin, Andrew B Gill, Andrew N Priest, David Y Lewis, Roslin Russell, Ashley Grimmer, Brian White, Beth Latimer-Bowman, Ilse Patterson, Amy Schiller, Bruno Carmo, Rhys Slough, Titus Lanz, James M S Wason, Rolf F Schulte, Suet-Feung Chin, Martin J Graves, Fiona J Gilbert, Jean E Abraham, Carlos Caldas, Kevin M Brindle, Evis Sala, Ferdia A Gallagher
Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients. Cancer research 81 (23) (2021)
Vencel Somai, Felix Kreis, Adam Gaunt, Anastasia Tsyben, Ming Li Chia, Friederike Hesse, Alan J Wright, Kevin M Brindle
Genetic algorithm-based optimization of pulse sequences. Magnetic resonance in medicine (2021)
Ramona Woitek, Mary A McLean, Andrew B Gill, James T Grist, Elena Provenzano, Andrew J Patterson, Stephan Ursprung, Turid Torheim, Fulvio Zaccagna, Matthew Locke, Marie-Christine Laurent, Sarah Hilborne, Amy Frary, Lucian Beer, Leonardo Rundo, Ilse Patterson, Rhys Slough, Justine Kane, Heather Biggs, Emma Harrison, Titus Lanz, Bristi Basu, Richard Baird, Evis Sala, Martin J Graves, Fiona J Gilbert, Jean E Abraham, Carlos Caldas, Kevin M Brindle, Ferdia A Gallagher
Hyperpolarized 13C MRI of Tumor Metabolism Demonstrates Early Metabolic Response to Neoadjuvant Chemotherapy in Breast Cancer. Radiology. Imaging cancer 2 (4) (2020)
Valentí Gómez, Thomas R Eykyn, Rami Mustapha, Fabian Flores-Borja, Victoria Male, Paul R Barber, Antonia Patsialou, Ryan Green, Fani Panagaki, Chun W Li, Gilbert O Fruhwirth, Susana Ros, Kevin M Brindle, Tony T Ng
Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells. Science signaling 13 (652) (2020)
Felix Kreis, Alan J Wright, Vencel Somai, Rachel Katz-Brull, Kevin M Brindle
Increasing the sensitivity of hyperpolarized [15 N2 ]urea detection by serial transfer of polarization to spin-coupled protons. Magnetic resonance in medicine 84 (4) (2020)
Vencel Somai, Alan J Wright, Maria Fala, Friederike Hesse, Kevin M Brindle
A multi spin echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized 13 C imaging. Magnetic resonance in medicine 84 (4) (2020)
Flaviu Bulat, Friederike Hesse, De-En Hu, Susana Ros, Connor Willminton-Holmes, Bangwen Xie, Bala Attili, Dmitry Soloviev, Franklin Aigbirhio, Finian J Leeper, Kevin M Brindle, André A Neves
18F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography. EJNMMI research 10 (1) (2020)
Florent Mouliere, Dineika Chandrananda, Anna M Piskorz, Elizabeth K Moore, James Morris, Lise Barlebo Ahlborn, Richard Mair, Teodora E Goranova, Francesco Marass, Katrin Heider, Jonathan C M Wan, Anna Supernat, Irena Hudecova, Ioannis Gounaris, Susana Ros, Mercedes Jimenez-Linan, Javier Garcia-Corbacho, Keval Patel, Olga Østrup, Suzanne Murphy, Matthew D Eldridge, Davina Gale, Grant D Stewart, Johanna Burge, Wendy N Cooper, Michiel S van der Heijden, Charles E Massie, Colin Watts, Philippa Corrie, Simon Pacey, Kevin M Brindle, Richard D Baird, Morten Mau Sorensen, Christine A Parkinson, Christopher G Smith, James D Brenton, Nitzan Rosenfeld
Enhanced detection of circulating tumor DNA by fragment size analysis. Science translational medicine 10 (466) (2019)
Felix Kreis, Alan J Wright, Friederike Hesse, Maria Fala, De-En Hu, Kevin M Brindle
Measuring Tumor Glycolytic Flux in Vivo by Using Fast Deuterium MRI. Radiology 294 (2) (2019)
Florent Mouliere, Richard Mair, Dineika Chandrananda, Francesco Marass, Christopher G Smith, Jing Su, James Morris, Colin Watts, Kevin M Brindle, Nitzan Rosenfeld
Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients. EMBO molecular medicine 10 (12) (2019)
Dmitry Shishmarev, Alan J Wright, Tiago B Rodrigues, Giuseppe Pileio, Gabriele Stevanato, Kevin M Brindle, Philip W Kuchel
Sub-minute kinetics of human red cell fumarase: 1 H spin-echo NMR spectroscopy and 13 C rapid-dissolution dynamic nuclear polarization. NMR in biomedicine 31 (3) (2018)
Jiazheng Wang, Richard L Hesketh, Alan J Wright, Kevin M Brindle
Hyperpolarized 13 C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses. NMR in biomedicine 31 (11) (2018)
E M Serrao, Mikko I Kettunen, T B Rodrigues, D Y Lewis, F A Gallagher, D E Hu, Kevin M Brindle
Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate. NMR in biomedicine 31 (5) (2018)
Dmitry Shishmarev, Philip W Kuchel, Guilhem Pagès, Alan J Wright, Richard L Hesketh, Felix Kreis, Kevin M Brindle
Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal. Communications biology 1 (2018)
Alan J Wright, Zoé M A Husson, De-En Hu, Gerard Callejo, Kevin M Brindle, Ewan St John Smith
Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate. NMR in biomedicine 31 (4) (2018)
Jiazheng Wang, Alan J Wright, Richard L Hesketh, De-En Hu, Kevin M Brindle
A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate. NMR in biomedicine 31 (2) (2017)
André A Neves, Yéléna A Wainman, Alan Wright, Mikko I Kettunen, Tiago B Rodrigues, Sarah McGuire, De-En Hu, Flaviu Bulat, Simonetta Geninatti Crich, Henning Stöckmann, Finian J Leeper, Kevin M Brindle
Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging. Angewandte Chemie (International ed. in English) 55 (4) (2015)
André A Neves, Yéléna A Wainman, Alan Wright, Mikko I Kettunen, Tiago B Rodrigues, Sarah McGuire, De-En Hu, Flaviu Bulat, Simonetta Geninatti Crich, Henning Stöckmann, Finian J Leeper, Kevin M Brindle
Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 128 (4) (2015)