Cytokeratin expression in plasmablastic lymphoma - a possible diagnostic pitfall in the routine work-up of tumours.

Katrin S HuettlAnnette M StaigerHeike HornFabian FrontzekJohn R GoodladGustavo TapiaAndreas RosenwaldWolfram KlapperFalko FendFina ClimentJosep CastellviAlexandar TzankovStefan DirnhoferMaria João BaptistaJosé-Tomas NavarroIoannis AnagnostopoulosWolfgang HartmannGeorg LenzGerman Ott

Published in: Histopathology (2020)

Our data indicate CK expression in a substantial number (15%) of PBLs. In view of the particular morphological features of PBL and its frequent negativity for the common leukocyte antigen and B-cell markers, this feature represents a pitfall in the routine diagnostic work-up of PBL, and requires more extensive immunohistochemical and molecular characterisation of cases entering the differential diagnosis.

Keyphrases

poor prognosis
clinical practice
machine learning
diffuse large b cell lymphoma
electronic health record
deep learning
big data
long non coding rna
peripheral blood