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HDAC3 Inhibition Alleviates High-Glucose-Induced Retinal Ganglion Cell Death through Inhibiting Inflammasome Activation.

Dongyi YuQing TangLili LiuDawei HeLibo WangXin Zhou
Published in: BioMed research international (2022)
. In conclusion, HDAC3 was involved in RGC loss and thus promoted the progression of neurodegeneration of DR. Besides, HDAC3 inhibitor demonstrated protective effects in neurodegeneration in DR through downregulation of NLRP3 activity. The effects of HDAC3 inhibitor in DR management should be confirmed in clinical trials.
Keyphrases
  • high glucose
  • histone deacetylase
  • endothelial cells
  • cell death
  • editorial comment
  • clinical trial
  • signaling pathway
  • randomized controlled trial
  • mouse model
  • nlrp inflammasome
  • study protocol
  • open label