Effects of novel androgen receptor signaling inhibitors on PSMA PET signal intensity in patients with castrate-resistant prostate cancer: a prospective exploratory serial imaging study.

Ida SonniAndrei GafitaLena M UnterrainerRejah M AlanoStephanie LiraJohn ShenAlexandra DrakakiTristan GroganMatthew B RettigJohannes CzerninJeremie Calais

Published in: EJNMMI research (2023)

Our prospective trial involving 9 mCRPC patients initiating ARSi did not show significant modulation of PSMA expression measured on WB-PSMA PET at 1-week. This study was registered on clinicaltrials.gov (NCT04279561).

Keyphrases

pet ct
pet imaging
prostate cancer
computed tomography
positron emission tomography
poor prognosis
ejection fraction
newly diagnosed
clinical trial
high resolution
study protocol
radical prostatectomy
high intensity
open label
phase ii
mass spectrometry