Zika virus found in brain tissue of a multiple sclerosis patient undergoing an acute disseminated encephalomyelitis-like episode.
Soniza Vieira Alves-LeonMonique da Rocha LimaPriscila Conrado Guerra NunesLeila Maria Cardão ChimelliKíssila RabeloRita Maria Ribeiro NogueiraFernanda de Bruycker-NogueiraElzinandes Leal de AzeredoPaulo Roberto BahiaFernanda Cristina Rueda LopesJorge P Barreto Marcondes de SouzaFabrícia Lima Fontes-DantasMarciano Viana PaesElba Rs LemosFlavia Barreto SantosPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2018)
Our data describe the coexistence of a recent central nervous system (CNS) ZIKV infection accompanied by a severe ADEM-like syndrome outcome in a patient with clinical history of MS. A de novo immune response concomitant with ZIKV infection might be involved in the mechanism of the ADEM-like syndrome and response to immunotherapy. The present report reinforces the importance of providing the differential diagnosis of acute episodes of MS exacerbation in an environment prone to ZIKV expression.
Keyphrases
- zika virus
- multiple sclerosis
- case report
- liver failure
- respiratory failure
- dengue virus
- immune response
- white matter
- mass spectrometry
- drug induced
- aedes aegypti
- ms ms
- poor prognosis
- chronic obstructive pulmonary disease
- aortic dissection
- early onset
- blood brain barrier
- electronic health record
- hepatitis b virus
- big data
- dendritic cells
- intensive care unit
- resting state
- machine learning
- brain injury