The angiogenic properties of human amniotic membrane stem cells are enhanced in gestational diabetes and associate with fetal adiposity.
Sergiy KlidFrancisco Algaba-ChuecaElsa Maymó-MasipAlbert GuarqueMónica BallesterosCristina Diaz-PerdigonesCristina GutierrezJoan VendrellAna MegíaSonia Fernández-VeledoPublished in: Stem cell research & therapy (2021)
GDM exposure contributes to the angiogenic abilities of hAMSCs, which are further related to increased cord blood insulin and fetal adiposity. PAI-1 emerges as a potential key player of GDM-induced angiogenesis.
Keyphrases
- cord blood
- endothelial cells
- high glucose
- stem cells
- insulin resistance
- type diabetes
- weight gain
- diabetic rats
- drug induced
- vascular endothelial growth factor
- induced pluripotent stem cells
- pluripotent stem cells
- cell therapy
- glycemic control
- human health
- pregnant women
- metabolic syndrome
- oxidative stress
- physical activity
- wound healing
- bone marrow
- weight loss