Genetic risk for chronic pain is associated with lower antidepressant effectiveness: Converging evidence for a depression subtype.

Adrian I CamposTrung Thanh NgoSarah E MedlandNaomi R WrayIan B HickieEnda M ByrneNicholas G MartinMiguel E Rentería

Published in: The Australian and New Zealand journal of psychiatry (2021)

These results suggest genetic risk for chronic pain accounted for poorer antidepressant effectiveness, independent of the genetic risk for major depression. Our results, along with independent converging evidence from other studies, point towards a difficult-to-treat depression subtype characterised by comorbid chronic pain. This finding warrants further investigation into the implications for biologically based nosology frameworks in pain medicine and psychiatry.

Keyphrases

chronic pain
pain management
randomized controlled trial
depressive symptoms
systematic review
genome wide
major depressive disorder
copy number
sleep quality
gene expression
dna methylation
case control