Peptides derived from the integrin β cytoplasmic tails inhibit angiogenesis.
Zhongyuan CaoXinfeng SuoYudan ChuZhou XuYun BaoChunxiao MiaoWenfeng DengKaijun MaoJuan GaoZhen XuYan-Qing MaPublished in: Cell communication and signaling : CCS (2018)
Our results suggest that the antiangiogenic mβCTPs can interact with β3-endonexin in vascular endothelial cells and suppress its function in regulating VEGF expression and cell proliferation, thus disclosing a unique pathway that may be useful for developing novel antiangiogenic strategies.