Evolved resistance to a novel cationic peptide antibiotic requires high mutation supply.
Alfonso Santos-LopezMelissa J FritzJeffrey B LombardoAnsen H P BurrVictoria A HeinrichChristopher W MarshallVaughn S CooperPublished in: Evolution, medicine, and public health (2022)
The results show how experimental evolution and WGS can identify genetic targets and actions of new antimicrobial compounds and predict pathways to resistance of new antibiotics in clinical practice.