Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?
Mayur GargSimon G RoyceChris TikellisClaire ShallueDuygu BatuElena VelkoskaLouise M BurrellSheila K PatelLauren BeswickAnvesh JacksonKaushali BrittoMatthew LukiesPavel SlukaHady WardanYumiko HirokawaChin Wee TanMaree FauxAntony W BurgessPatrick HoskingShaun MonagleMerlin ThomasPeter R GibsonJohn LubelPublished in: Gut (2019)
The RAS mediates fibrosis in human cell cultures, is expressed in the intestine and perturbed in intestinal inflammation, and agents targeting this system are associated with improved disease outcomes.