Gut microbiota perturbation is associated with acute sleep disturbance among rectal cancer patients.
Velda Janet Gonzalez-MercadoAnujit SarkarFrank J PenedoJosué Pérez-SantiagoSusan McMillanSara Janet MarreroMiguel A Marrero-FalcónCindy L MunroPublished in: Journal of sleep research (2019)
Cancer treatment-associated gut microbial perturbation/dysbiosis has been implicated in the pathobiology of sleep disturbance; however, evidence is scarce. Eighteen newly diagnosed rectal cancer patients (ages 52-81 years; 10 males) completed a sleep disturbance questionnaire and provided stool samples for 16s RNA gene sequencing during chemo-radiotherapy. Descriptive statistics, Wilcoxon test and regression analyses were computed. Regression analyses showed the Shannon's diversity index to be a significant factor associated with sleep disturbance. This preliminary work suggests that the biological "gut-brain axis" mechanism may be associated with symptoms of sleep disturbance.
Keyphrases
- newly diagnosed
- sleep quality
- rectal cancer
- physical activity
- locally advanced
- end stage renal disease
- cross sectional
- early stage
- ejection fraction
- photodynamic therapy
- depressive symptoms
- intensive care unit
- magnetic resonance imaging
- radiation therapy
- microbial community
- copy number
- genome wide
- computed tomography
- patient reported
- cerebral ischemia
- cancer therapy
- respiratory failure
- brain injury
- diffusion weighted imaging
- aortic dissection