Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis.
Shuai TanShuijie LiYanan MinAnton GisteråNoah MoruzziJunhao ZhangYang SunJohn AnderssonRickard E MalmströmMiao WangPer-Olof BerggrenSusanne SchlisioWangjun LiaoDaniel F J KetelhuthChunhong MaChunyang LiPublished in: Journal of thrombosis and haemostasis : JTH (2020)
Platelets enhance CD4+ T cell responses of Tem cells through PF4-dependent and Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis. Hence, PF4 may be a promising intervention target of platelet-regulated immune responses.