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Strict glucose control and elimination of NLRP3-induced inflammation prevents diabetic bladder dysfunction in the female Akita mouse model.

Francis M HughesShelby N HarperHuixia JinMichael R OdomJ Todd Purves
Published in: Neurourology and urodynamics (2024)
Early-initiated strict glycemic control and NLRP3 elimination can effectively prevent DBD, suggesting hyperglycemia acts through NLRP3-induced inflammation to trigger DBD.
Keyphrases
  • oxidative stress
  • diabetic rats
  • glycemic control
  • mouse model
  • type diabetes
  • high glucose
  • blood glucose
  • nlrp inflammasome
  • drug induced
  • endothelial cells
  • weight loss
  • blood pressure
  • skeletal muscle
  • insulin resistance