Oxidative, inflammatory, genetic, and epigenetic biomarkers associated with chronic obstructive pulmonary disorder.
Taru AggarwalRidhima WadhwaNoopur ThapliyalKanishka SharmaVarsha RaniPawan Kumar MauryaPublished in: Journal of cellular physiology (2018)
A large body of evidence indicates that chronic obstructive pulmonary disorder (COPD) is accompanied by oxidative stress and inflammatory and genetic pathways. Epidemiological studies indicate that COPD is a major cause of mortality and morbidity in the world. Recent research development in COPD focuses on accelerated aging and various oxidative stress biomarkers. It involves the clinical manifestation of the disease process and may also contain biochemical, immunological, physiological, morphological, and genetic aspects that add to the progressiveness of the disease. Herein, we summarize findings that highlight the role of dimensions of COPD in the investigation of oxidative stress, inflammatory responses, genetic and epigenetic studies, and pharmacological and dietary antioxidant intervention.
Keyphrases
- oxidative stress
- chronic obstructive pulmonary disease
- lung function
- genome wide
- dna methylation
- dna damage
- diabetic rats
- pulmonary hypertension
- copy number
- induced apoptosis
- randomized controlled trial
- gene expression
- cardiovascular events
- cystic fibrosis
- risk factors
- cardiovascular disease
- signaling pathway
- case control
- coronary artery disease