Impact of MEK Inhibitor Therapy on Neurocognitive Functioning in NF1.

Karin S WalshPamela L WoltersBrigitte C WidemannAllison Del CastilloMaegan D SadyTess InkerMarie Claire RoderickStaci MartinMary Anne Toledo-TamulaKari StruemphIris PaltinVictoria CollierKathy MullinMichael J FisherRoger J Packer

Published in: Neurology. Genetics (2021)

Our data show no evidence of neurotoxicity in 48 weeks of treatment with an MEKi and a potential clinical signal supporting future research of MEKi as a cognitive intervention.

Keyphrases

randomized controlled trial
pi k akt
signaling pathway
electronic health record
lps induced
current status
oxidative stress
big data
stem cells
nuclear factor
combination therapy
human health
immune response
risk assessment
climate change
replacement therapy
deep learning
toll like receptor
smoking cessation