Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease.
Victor A Del BeneRoy C MartinSarah A BrinkerhoffJoseph W OlsonMatthew J NelsonDario MarottaChristopher L GonzalezKelly A MillsVidyulata KamathGary CutterChris P HurtMelissa WadeFrank G RobinsonJ Nicole BentleyBarton L GuthrieRobert T KnightHarrison C WalkerPublished in: Annals of neurology (2024)
Directional versus ring STN DBS did not differentially affect cognition. Similar to prior bilateral DBS studies, unilateral left stimulation worsened verbal fluency performance. In contrast, unilateral right STN surgery increased performance on verbal fluency and response inhibition tasks. Our findings raise the hypothesis that unilateral right STN DBS in selected patients with predominant right brain motor parkinsonism could mitigate declines in verbal fluency associated with the bilateral intervention. ANN NEUROL 2024.
Keyphrases
- deep brain stimulation
- parkinson disease
- working memory
- obsessive compulsive disorder
- white matter
- randomized controlled trial
- minimally invasive
- magnetic resonance
- resting state
- case report
- mild cognitive impairment
- coronary artery bypass
- drug induced
- computed tomography
- blood brain barrier
- brain injury
- case control