Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.
Ruinan ShenXiaobei ZhaoLu HeYongbo DingWei XuSuzhen LinSavannah FangWanlin YangKijung SungBrian SpencerRobert A RissmanMing LeiJianqing DingChengbiao WuPublished in: Translational neurodegeneration (2020)
RIN3 is significantly upregulated and correlated with endosomal dysfunction in APP/PS1 mouse. Through interacting with BIN1 and CD2AP, increased RIN3 expression alters axonal trafficking and procession of APP. Together with our previous studies, our current work has thus provided important insights into the role of RIN3 in regulating endosomal signaling and trafficking.