Polygonogram with isobolographic synergy for three-drug combinations of phenobarbital with second-generation antiepileptic drugs in the tonic-clonic seizure model in mice.
Jarogniew J LuszczkiDominika PodgórskaJustyna KozińskaMarek JankiewiczZbigniew PlewaMateusz KominekDorota ŻółkowskaMagdalena Florek-ŁuszczkiPublished in: Pharmacological reports : PR (2020)
The synergistic interactions among PB and LTG, OXC, PGB and TPM in the mouse MES model are worthy of being transferred to clinical trials, especially for the patients with drug resistant epilepsy, who would benefit these treatment options.