Tcf-1 protects anti-tumor TCR-engineered CD8 + T-cells from GzmB mediated self-destruction.

Brendan ZangariTakemasa TsujiJunko MatsuzakiHemn MohammadpourCheryl EppolitoSebastiano BattagliaFumito ItoThinle ChodonRichard KoyaA J Robert McGrayKunle Odunsi

Published in: Cancer immunology, immunotherapy : CII (2022)

T cells from activation induced cell death by restricting GzmB expression. Our study presents constitutive Tcf-1B expression as a potential means to impart therapeutic T cells with attributes of persistence for durable anti-tumor activity.

Keyphrases

poor prognosis
cell death
binding protein
long non coding rna
regulatory t cells
diabetic rats
immune response
dendritic cells