ATM mutations associate with distinct co-mutational patterns and therapeutic vulnerabilities in NSCLC.

Natalie I Vokes Ana Galan Cobo Margarita Fernandez-Chas David P Molkentine Santiago Treviño Vitaly Druker Yu Qian Sonia A Patel Stephanie Tzouanas Schmidt Lingzhi Hong Jeff Lewis Waree Rinsurongkawong Vadeerat Rinsurongkawong Jiun-Kae Jack Lee Marcelo Vailati Negrão Don L Gibbons Ara A Vaporciyan Xiuning Le Jia Wu Jianjun Zhang Una Rigney Sonia Iyer Emma Dean John Victor Heymach

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

ATM mutations define a distinct subset of NSCLC associated with KRAS mutations, increased TMB, decreased TP53 and EGFR co-occurrence, and potential increased sensitivity to ICIs in the context of DNA-damaging chemotherapy.

Keyphrases

small cell lung cancer
dna damage
advanced non small cell lung cancer
dna repair
dna damage response
epidermal growth factor receptor
tyrosine kinase
brain metastases
single molecule
squamous cell carcinoma
risk assessment
radiation therapy
climate change
circulating tumor cells