Characterization of the renal cortical transcriptome following Roux-en-Y gastric bypass surgery in experimental diabetic kidney disease.
Meera NairWilliam P MartinVadim ZhernovkovJessie A ElliottNaomi FearonHans EckhardtJanet McCormackCatherine GodsonEoin Patrick BrennanLars FandriksNeil G DochertyCarel W le RouxPublished in: BMJ open diabetes research & care (2021)
Improved glomerular structure in ZDF rats following RYGB is underpinned by pathway level changes, including interruption of the TGF-β-driven early profibrotic programme. Our data provide an important layer of experimental support for clinical evidence demonstrating that RYGB arrests renal damage in patients with obesity and type 2 diabetes.
Keyphrases
- roux en y gastric bypass
- weight loss
- type diabetes
- gastric bypass
- obese patients
- bariatric surgery
- glycemic control
- insulin resistance
- minimally invasive
- coronary artery bypass
- metabolic syndrome
- gene expression
- cardiovascular disease
- genome wide
- transforming growth factor
- electronic health record
- rna seq
- high fat diet induced
- weight gain
- study protocol
- randomized controlled trial
- big data
- cardiopulmonary resuscitation
- physical activity
- cardiac arrest
- body mass index
- adipose tissue
- wound healing
- high glucose
- signaling pathway
- data analysis
- surgical site infection
- artificial intelligence
- deep learning
- atrial fibrillation
- skeletal muscle