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Characterization of the renal cortical transcriptome following Roux-en-Y gastric bypass surgery in experimental diabetic kidney disease.

Meera NairWilliam P MartinVadim ZhernovkovJessie A ElliottNaomi FearonHans EckhardtJanet McCormackCatherine GodsonEoin Patrick BrennanLars FandriksNeil G DochertyCarel W le Roux
Published in: BMJ open diabetes research & care (2021)
Improved glomerular structure in ZDF rats following RYGB is underpinned by pathway level changes, including interruption of the TGF-β-driven early profibrotic programme. Our data provide an important layer of experimental support for clinical evidence demonstrating that RYGB arrests renal damage in patients with obesity and type 2 diabetes.
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