Hippocampal Metabolic Alterations in Amyotrophic Lateral Sclerosis: A Magnetic Resonance Spectroscopy Study.
Foteini ChristidiGeorgios D ArgyropoulosEfstratios KaravasilisGeorgios VelonakisVasiliki ZouvelouPanagiotis KourtesisVarvara PantoleonEe Ling TanAriadne DaponteStavroula AristeidouSophia XirouPanagiotis FerentinosIoannis EvdokimidisMichail RentzosIoannis SeimenisPeter BedePublished in: Life (Basel, Switzerland) (2023)
Hippocampal 1H-MRS may not only contribute to a better academic understanding of extra-motor disease burden in ALS, but given its sensitive correlations with validated clinical metrics, it may serve as practical biomarker for future clinical and clinical trial applications. Neuroimaging protocols in ALS should incorporate MRS in addition to standard structural, functional, and diffusion sequences.