Phenotypic Expression, Natural History, and Risk Stratification of Cardiomyopathy Caused by Filamin C Truncating Variants.

Marta GigliDavide StolfoSharon L GrawMarco MerloCaterina GregorioSuet Nee ChenMatteo Dal FerroAlessia PaldinoMDGiulia De AngelisFrancesca BrunJean JirikowicErnesto E SalcedoSylvia TurjaDiane FatkinRenee JohnsonJ Peter van TintelenAnneline S J M Te RieleArthur A M WildeNeal K LakdawalaKermshlise PicardDaniela MianiDaniele MuserGiovanni Maria Severini Hugh CalkinsCynthia A JamesBrittney MurrayCrystal TichnellVictoria N ParikhEuan A Ashley Nicolette ChunJiangping SongDaniel P JudgeWilliam J McKennaMatthew R G TaylorGianfranco Sinagra

Published in: Circulation (2021)

Among patients referred to tertiary referral centers, FLNCtv arrhythmogenic cardiomyopathy is phenotypically heterogeneous and characterized by a high risk of life-threatening arrhythmias, which does not seem to be associated with the severity of left ventricular dysfunction.

Keyphrases

heart failure
left ventricular
poor prognosis
primary care
copy number
oxidative stress
hypertrophic cardiomyopathy
cardiac resynchronization therapy
binding protein
congenital heart disease
mitral valve
aortic stenosis
long non coding rna
coronary artery disease
aortic valve
genome wide