From biochemical markers to molecular endotypes of osteoarthritis: a review on validated biomarkers.

Monica T HannaniChristian S ThudiumMorten A KarsdalChristoph LadelAli MobasheriMelanie UebelhoerJonathan LarkinJaume BacarditAndré StruglicsAnne-Christine Bay-Jensen

Published in: Expert review of molecular diagnostics (2024)

As utilized in IMI-APPROACH and validated in OAI-FNIH, a panel of biochemical markers may uncover disease subgroups and facilitate the enrichment of treatable molecular endotypes for recruitment in therapeutic clinical trials. Understanding the link between biochemical markers and patient-reported outcomes and treatable endotypes that may respond to given therapies will pave the way for new drug development in OA.

Keyphrases

patient reported outcomes
clinical trial
knee osteoarthritis
rheumatoid arthritis
single molecule
randomized controlled trial
open label