A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.
Xin XiaXixi LiFanying LiXujia WuMaolei ZhangHuangkai ZhouNunu HuangXuesong YangFeizhe XiaoDawei LiuLixuan YangNu ZhangPublished in: Molecular cancer (2019)
Our data indicate that the impaired circRNA expression of the AKT3 gene contributes to GBM tumorigenesis, and our data corroborate the hypothesis that restoring AKT3-174aa while inhibiting activated AKT may provide more benefits for certain GBM patients.
Keyphrases
- signaling pathway
- cell proliferation
- end stage renal disease
- electronic health record
- ejection fraction
- newly diagnosed
- chronic kidney disease
- poor prognosis
- big data
- binding protein
- prognostic factors
- genome wide
- copy number
- dna methylation
- small molecule
- data analysis
- machine learning
- protein protein
- tyrosine kinase
- transcription factor
- protein kinase
- artificial intelligence