Integrated metabolomics and transcriptomics revealed the anti-constipation mechanisms of xylooligosaccharides from corn cobs.
Hong SongRui GuoXianbao SunYuxing KouXuan MaYinan ChenLihua SongYan WuPublished in: Food & function (2024)
Xylooligosaccharides (XOSs) have recently garnered interest for their potential as an anti-constipation agent. In this study, we investigated the effects of XOSs derived from corn cobs on constipation in mice through a comprehensive analysis of both the metabolome and transcriptome. Our multi-omics approach revealed that XOSs primarily modulated butanoate metabolism and steroid hormone biosynthesis pathways, as well as key signaling pathways such as PPAR and NF-kappa B. Notably, we observed a decrease in inflammatory biomarker expression and an elevation of butyric acid metabolite levels with XOSs treatment. A deeper analysis of gene expression and metabolite alterations highlighted significant changes in genes encoding critical enzymes and metabolites involved in these pathways. Overall, these findings underscore the considerable potential of XOSs derived from corn cobs as a dietary supplement for effectively alleviating constipation.
Keyphrases
- single cell
- irritable bowel syndrome
- gene expression
- signaling pathway
- rna seq
- nuclear factor
- genome wide
- poor prognosis
- oxidative stress
- dna methylation
- mass spectrometry
- pi k akt
- metabolic syndrome
- human health
- lps induced
- insulin resistance
- type diabetes
- toll like receptor
- induced apoptosis
- climate change
- adipose tissue
- immune response
- transcription factor
- skeletal muscle