Human Epidermal Growth Factor Receptor 2-positive Mucinous Carcinoma with Signet Ring Cell Differentiation, Which Showed Complete Response after Neoadjuvant Chemotherapy.
Yunjeong JangEun Yoon ChoSoo Youn ChoPublished in: Journal of breast cancer (2019)
Mucinous carcinoma (MC) is a rare subtype of breast cancer, which is composed of tumor cells floating in the abundant extracellular mucin. This form of cancer is usually estrogen receptor/progesterone receptor positive and human epidermal growth factor receptor 2 (HER2) negative. Here, we present a case of HER2-positive MC with an unusual signet ring cell differentiation. It is very rare that a breast tumor consists entirely of signet ring cells. The tumor showed pathologic complete response (pCR) after neoadjuvant chemotherapy with trastuzumab and pertuzumab. pCR of HER2-positive MC has rarely been described in literature. It is important to consider the biological heterogeneity of MCs for effective management.
Keyphrases
- epidermal growth factor receptor
- neoadjuvant chemotherapy
- tyrosine kinase
- estrogen receptor
- advanced non small cell lung cancer
- locally advanced
- lymph node
- sentinel lymph node
- endothelial cells
- systematic review
- induced pluripotent stem cells
- induced apoptosis
- pluripotent stem cells
- early stage
- single cell
- oxidative stress
- cell death
- childhood cancer
- metastatic breast cancer