The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function.
Katrin NitzMichael LacyMariaelvy BianchiniKanin WichapongIrem Avcilar KücükgözeCecilia A BonfiglioRoberta MigheliYuting WuCarina BurgerYuanfang LiIgnasi ForneConstantin AmmarAleksandar JanjicSarajo MohantaJohan DucheneJohan W M HeemskerkRemco T A MegensEdzard SchwedhelmStephan HuveneersCraig A LygateDonato SantovitoRalf ZimmerAxel ImhofChristian WeberEsther LutgensDorothee AtzlerPublished in: Circulation research (2022)
Our study unravels a novel mechanism by which the amino acid homoarginine reduces atherosclerosis, establishing that homoarginine modulates the T-cell cytoskeleton and thereby mitigates T-cell functions important during atherogenesis. These findings provide a molecular explanation for the beneficial effects of homoarginine in atherosclerotic cardiovascular disease.