Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice.

Jiawei LiaoXiaolei YangQiuyue LinShuang LiuYunpeng Xie Yun-Long Xia Yun-Long Zhang

Published in: Journal of immunology research (2020)

We demonstrated that UBA1 expression was upregulated and mainly derived from macrophages in the atherosclerotic plaques and inactivation of UBA1 by PYR-41 suppressed atherosclerosis development probably through inhibiting macrophage proinflammatory response and oxidative stress. Our data suggested that UBA1 might be explored as a potential pharmaceutical target against atherosclerosis.

Keyphrases

signaling pathway
cardiovascular disease
oxidative stress
poor prognosis
adipose tissue
dna damage
electronic health record
type diabetes
induced apoptosis
small molecule
big data
machine learning
binding protein
diabetic rats
data analysis
heat shock