The gut microbiome in the fight against obesity: The potential of dietary factors.
Jamil AhmadImran KhanMuhammad Imran TousifMohamad Fawzi MahomodallyPublished in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2023)
Obesity as a global public health burden has experienced a drastic growing trend recently. The management of obesity is challenging because of its complex etiology, and various factors are involved in its development, such as genetic and environmental factors. Different approaches are available to treat and/or manage obesity, including diet, physical activity, lifestyle changes, medications, and surgery. However, some of these approaches have inherent limitations and are closely associated with adverse effects. Therefore, probing into a novel/safe approach to treat and/or manage obesity is of fundamental importance. One such approach gaining renewed interest is the potential role of gut microbiota in obesity and its effectiveness in treating this condition. However, there is a dearth of comprehensive compilation of data on the potential role of the gut microbiome in obesity, particularly regarding dietary factors as a therapeutic approach. Therefore, this review aims to provide an updated overview of the role of gut microbiota in obesity, further highlighting the importance of dietary factors, particularly diet, prebiotics, and probiotics, as potential complementary and/or alternative therapeutic options. Moreover, the association of gut microbiota with obese or lean individuals has also been discussed.
Keyphrases
- weight loss
- metabolic syndrome
- insulin resistance
- type diabetes
- high fat diet induced
- physical activity
- weight gain
- bariatric surgery
- public health
- adipose tissue
- randomized controlled trial
- coronary artery disease
- depressive symptoms
- minimally invasive
- machine learning
- gene expression
- atrial fibrillation
- genome wide
- copy number
- data analysis
- bone mineral density
- artificial intelligence
- electronic health record