TNF-α inhibits GDNF levels in Sertoli cells, through a NF-κB-dependent, HES1-dependent mechanism.

Sara Di PersioDonatella StaraceChiara CapponiRossana SaracinoStefania FeraAntonio FilippiniElena Vicini

Published in: Andrology (2021)

Because of the importance of GDNF for spermatogonial stem cell self-renewal and proliferation, this data may give important insights on how cytokine signals in the testis modulate the expression of niche-derived factors.

Keyphrases

stem cells
signaling pathway
induced apoptosis
poor prognosis
rheumatoid arthritis
cell cycle arrest
oxidative stress
electronic health record
machine learning
endoplasmic reticulum stress
big data
binding protein
inflammatory response
immune response
mesenchymal stem cells
cell proliferation
toll like receptor