Sex Hormones in Women With Elevated Breast Cancer Risk Undergoing Weight Loss.
Sophia A StoneClaire J HanTaurence SennLarissa A KordeKristen AllottScott RedingDale WhittingtonKerryn W RedingPublished in: Western journal of nursing research (2019)
Sedentary lifestyles and obesity are known risk factors for breast cancer. Elevated estrogen levels correlate with obesity and, independently, with increased breast cancer risk. Lifestyle interventions that reduce obesity may mitigate this risk, potentially via estrogen pathways. In a 6-month lifestyle intervention, overweight/obese women with high breast cancer risk were randomized to control (n = 7) or intervention (n = 6) and analyzed for sex hormone levels. Serum and urine hormones were evaluated by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and sex hormone binding globulin (SHBG) by enzyme-linked immunosorbent assay (ELISA). Serum estrone (E1) and estradiol (E2) were reduced by 12.1% and 50.8%, respectively, at 9 months in the intervention group, which differed from controls (p = .043 and .020). This contrasted with a 73.3% increase in urine E1 at 6 months in the intervention group (p = .035). These results suggest that a lifestyle intervention led to a favorable estrogen profile in relation to breast cancer risk.
Keyphrases
- breast cancer risk
- weight loss
- bariatric surgery
- metabolic syndrome
- randomized controlled trial
- roux en y gastric bypass
- liquid chromatography tandem mass spectrometry
- physical activity
- ms ms
- gastric bypass
- weight gain
- insulin resistance
- type diabetes
- estrogen receptor
- simultaneous determination
- glycemic control
- double blind
- open label
- high throughput
- placebo controlled
- adipose tissue
- high resolution
- body mass index
- phase ii
- dna binding
- tandem mass spectrometry
- phase iii
- transcription factor