Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells.
Dan CaoXinhua SongLi CheXiaolei LiMaria G PiloGianpaolo VidiliAlberto PorcuAntonio SolinasAntonio CiglianoGiovanni M PesSilvia RibbackFrank DombrowskiXin ChenLei LiDiego F CalvisiPublished in: Liver international : official journal of the International Association for the Study of the Liver (2016)
The present study strongly suggests that both de novo synthetized and exogenous FA play a major role along hepatocarcinogenesis. Thus, combined suppression of LPL and FASN might be highly beneficial for the treatment of human HCC.