TGF-β-induced NKILA inhibits ESCC cell migration and invasion through NF-κB/MMP14 signaling.

Zhiliang LuZhaoli ChenYuan LiJingnan WangZhirong ZhangYun CheJianbing HuangShouguo SunShuangshuang MaoYuanyuan LeiYibo GaoJie He

Published in: Journal of molecular medicine (Berlin, Germany) (2018)

Long noncoding RNA NKILA could be remarkably upregulated by classical TGF-β signal pathway in ESCC. NKILA was significantly downregulated in esophageal squamous cell carcinoma and negatively correlated with TNM stage. NKILA inhibits ESCC cell metastasis via repressing MMP14 expression by suppressing the phosphorylation of IκBα and NF-κB activation.

Keyphrases

long noncoding rna
signaling pathway
single cell
cell therapy
transforming growth factor
lps induced
oxidative stress
poor prognosis
pi k akt
nuclear factor
cell migration
high glucose
inflammatory response
drug induced
bone marrow
immune response
endothelial cells