Analysis of Malaria Control Measures' Effectiveness Using Multistage Vector Model.

We analyze an epidemiological model to evaluate the effectiveness of multiple means of control in malaria-endemic areas. The mathematical model consists of a system of several ordinary differential equations and is based on a multi-compartment representation of the system. The model takes into account the multiple resting-questing stages undergone by adult female mosquitoes during the period in which they function as disease vectors. We compute the basic reproduction number [Formula: see text] and show that if [Formula: see text], the disease-free equilibrium is globally asymptotically stable (GAS) on the nonnegative orthant. If [Formula: see text], the system admits a unique endemic equilibrium (EE) that is GAS. We perform a sensitivity analysis of the dependence of [Formula: see text] and the EE on parameters related to control measures, such as killing effectiveness and bite prevention. Finally, we discuss the implications for a comprehensive, cost-effective strategy for malaria control.