Synthesis of Peptide Disulfide-Bond Mimics by Using Fully Orthogonally Protected Diaminodiacids.
Tao WangJian FanXiao-Xu ChenRui ZhaoYang XuDonald BiererSanling LiuYi-Ming LiJing ShiGe-Min FangPublished in: Organic letters (2018)
A new strategy was developed for the synthesis of peptide disulfide-bond mimics using fully orthogonally protected diaminodiacids. This method overcomes the previous problems of heavy-metal contamination and poor compatibility with Fmoc chemistry and provides a practical avenue for the efficient preparation of peptide disulfide-bond mimics.