The Combination of Zinc and Melatonin Enhanced Neuroprotection and Attenuated Neuropathy in Oxaliplatin-Induced Neurotoxicity.

Published in: Drug design, development and therapy (2022)

The combination of zinc with melatonin for the prevention approach was effective in attenuating neurotoxicity induced by oxaliplatin. The proposed mechanisms are boosting the antioxidant system and attenuating the expression of p53, GFAP, and TNF-α.

Keyphrases

oxide nanoparticles
poor prognosis
rheumatoid arthritis
high glucose
oxidative stress
diabetic rats
brain injury
anti inflammatory
drug induced
binding protein
cerebral ischemia
endothelial cells