Cell invasion, RAGE expression, and inflammation in oral squamous cell carcinoma (OSCC) cells exposed to e-cigarette flavoring.

Kary Y F TsaiKelsey M Hirschi BudgeAnthony P LepreMichael S RheesJanet AjdaharianJordy GeilerDaniel G EppersonKolten J AstleDuane R WindenJuan A ArroyoPaul R Reynolds

Published in: Clinical and experimental dental research (2020)

We conclude that electronic cigarette flavoring and nicotine orchestrate differential regulation of oral squamous cell carcinoma (OSCC) cell invasion and inflammatory effects. This study provides an important initial step in dissecting RAGE-mediated mechanisms of cancerous invasion and molecular avenues employed by OSCC.

Keyphrases

smoking cessation
oxidative stress
induced apoptosis
poor prognosis
cell migration
endoplasmic reticulum stress
cell proliferation