Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence.
Wenjing ZhaoFlorence CaroWilliam P RobinsJohn J MekalanosPublished in: Science (New York, N.Y.) (2018)
The bacterial type VI secretion system (T6SS) is a nanomachine that delivers toxic effector proteins into target cells, killing them. In mice, we found that the Vibrio cholerae T6SS attacks members of the host commensal microbiota in vivo, facilitating the pathogen's colonization of the gut. This microbial antagonistic interaction drives measurable changes in the pathogenicity of V. cholerae through enhanced intestinal colonization, expression of bacterial virulence genes, and activation of host innate immune genes. Because ablation of mouse commensals by this enteric pathogen correlated with more severe diarrheal symptoms, we conclude that antagonism toward the gut microbiota could improve the fitness of V. cholerae as a pathogen by elevating its transmission to new susceptible hosts.
Keyphrases
- biofilm formation
- candida albicans
- innate immune
- pseudomonas aeruginosa
- escherichia coli
- staphylococcus aureus
- genome wide
- induced apoptosis
- antimicrobial resistance
- poor prognosis
- cell cycle arrest
- physical activity
- bioinformatics analysis
- microbial community
- body composition
- regulatory t cells
- dendritic cells
- early onset
- cystic fibrosis
- high fat diet induced
- genome wide analysis
- dna methylation
- metabolic syndrome
- gene expression
- oxidative stress
- binding protein
- depressive symptoms
- drug induced
- long non coding rna