Exercise Reduces Airway Smooth Muscle Contraction in Asthmatic Rats via Inhibition of IL-4 Secretion and Store-Operated Ca 2+ Entry Pathway.

Jun-Hao Huang Hui-Wen Gao Dong-Dong GaoWei-Yue YangMeng-Ke ZhaoBing Shen Min Hu

Published in: Allergy, asthma & immunology research (2023)

The data in this study reveal that aerobic exercise may improve the ASM contractile function in asthmatic rats by inhibiting IL-4 secretion and by down-regulating the expression of STIM1, Orai1 and Orai2, thus decreasing excessive SOCE-mediated ASM contraction in asthmatic rats.

Keyphrases

smooth muscle
lung function
poor prognosis
genome wide
high intensity
big data
signaling pathway
gene expression
dna methylation
cystic fibrosis
long non coding rna
artificial intelligence
data analysis